Influence of lecithin-lipid composition on physico-chemical properties of nanoliposomes loaded with a hydrophobic molecule.
Identifieur interne : 000116 ( France/Analysis ); précédent : 000115; suivant : 000117Influence of lecithin-lipid composition on physico-chemical properties of nanoliposomes loaded with a hydrophobic molecule.
Auteurs : Lynda Bouarab [France] ; Behnoush Maherani [France] ; Azadeh Kheirolomoom [États-Unis] ; Mahmoud Hasan [France] ; Bahar Aliakbarian [Italie] ; Michel Linder [France] ; Elmira Arab-Tehrany [France]Source :
- Colloids and surfaces. B, Biointerfaces ; 2014.
English descriptors
- KwdEn :
- Animals, Calorimetry, Differential Scanning, Chromatography, Gas, Cinnamates (chemistry), Docosahexaenoic Acids (chemistry), Elastic Modulus, Electrophoresis, Hydrophobic and Hydrophilic Interactions, Lecithins (chemistry), Liposomes (chemistry), Liposomes (ultrastructure), Membrane Fluidity, Nanoparticles (chemistry), Nanoparticles (ultrastructure), Particle Size, Phase Transition, Rheology, Salmon, Solubility, Temperature, Viscosity.
- MESH :
- chemical , chemistry : Cinnamates, Docosahexaenoic Acids, Lecithins, Liposomes.
- chemical , ultrastructure : Liposomes.
- chemistry : Nanoparticles.
- ultrastructure : Nanoparticles.
- Animals, Calorimetry, Differential Scanning, Chromatography, Gas, Elastic Modulus, Electrophoresis, Hydrophobic and Hydrophilic Interactions, Membrane Fluidity, Particle Size, Phase Transition, Rheology, Salmon, Solubility, Temperature, Viscosity.
Abstract
In this work, we studied the effect of nanoliposome composition based on phospholipids of docosahexaenoic acid (PL-DHA), salmon and soya lecithin, on physico-chemical characterization of vector. Cinnamic acid was encapsulated as a hydrophobic molecule in nanoliposomes made of three different lipid sources. The aim was to evaluate the influence of membrane lipid structure and composition on entrapment efficiency and membrane permeability of cinnamic acid. These properties are important for active molecule delivery. In addition, size, electrophoretic mobility, phase transition temperature, elasticity and membrane fluidity were measured before and after encapsulation. The results showed a correlation between the size of the nanoliposome and the entrapment. The entrapment efficiency of cinnamic acid was found to be the highest in liposomes prepared from salmon lecithin. The nanoliposomes composed of salmon lecithin presented higher capabilities as a carrier for cinnamic acid encapsulation. These vesicles also showed a high stability which in turn increases the membrane rigidity of nanoliposome as evaluated by their elastic properties, membrane fluidity and phase transition temperature.
DOI: 10.1016/j.colsurfb.2013.11.034
PubMed: 24355384
Affiliations:
- France, Italie, États-Unis
- Alsace-Champagne-Ardenne-Lorraine, Californie, Lorraine
- Vandoeuvre-Lès-Nancy
- Université de Lorraine
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pubmed:24355384Le document en format XML
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Laboratoire d'Ingénierie des Biomolécules, 2, Avenue de la Forêt de Haye, F-54504 Vandoeuvre-Lès-Nancy Cedex, France. 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Hasan</name><affiliation wicri:level="4"><nlm:affiliation>Université de Lorraine, Laboratoire d'Ingénierie des Biomolécules, 2, Avenue de la Forêt de Haye, F-54504 Vandoeuvre-Lès-Nancy Cedex, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université de Lorraine, Laboratoire d'Ingénierie des Biomolécules, 2, Avenue de la Forêt de Haye, F-54504 Vandoeuvre-Lès-Nancy Cedex</wicri:regionArea><placeName><region type="region" nuts="2">Alsace-Champagne-Ardenne-Lorraine</region><region type="old region" nuts="2">Lorraine</region><settlement type="city">Vandoeuvre-Lès-Nancy</settlement></placeName><orgName type="university">Université de Lorraine</orgName></affiliation></author><author><name sortKey="Aliakbarian, Bahar" sort="Aliakbarian, Bahar" uniqKey="Aliakbarian B" first="Bahar" last="Aliakbarian">Bahar Aliakbarian</name><affiliation wicri:level="1"><nlm:affiliation>Department of Civil, Chemical and Environmental Engineering (DICCA), University of Genoa, 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Electronic address: elmira.arab-tehrany@univ-lorraine.fr.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université de Lorraine, Laboratoire d'Ingénierie des Biomolécules, 2, Avenue de la Forêt de Haye, F-54504 Vandoeuvre-Lès-Nancy Cedex</wicri:regionArea><placeName><region type="region" nuts="2">Alsace-Champagne-Ardenne-Lorraine</region><region type="old region" nuts="2">Lorraine</region><settlement type="city">Vandoeuvre-Lès-Nancy</settlement></placeName><orgName type="university">Université de Lorraine</orgName></affiliation></author></analytic><series><title level="j">Colloids and surfaces. B, Biointerfaces</title><idno type="e-ISSN">1873-4367</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Calorimetry, Differential Scanning</term><term>Chromatography, Gas</term><term>Cinnamates (chemistry)</term><term>Docosahexaenoic Acids (chemistry)</term><term>Elastic Modulus</term><term>Electrophoresis</term><term>Hydrophobic and Hydrophilic Interactions</term><term>Lecithins (chemistry)</term><term>Liposomes (chemistry)</term><term>Liposomes (ultrastructure)</term><term>Membrane Fluidity</term><term>Nanoparticles (chemistry)</term><term>Nanoparticles (ultrastructure)</term><term>Particle Size</term><term>Phase Transition</term><term>Rheology</term><term>Salmon</term><term>Solubility</term><term>Temperature</term><term>Viscosity</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Cinnamates</term><term>Docosahexaenoic Acids</term><term>Lecithins</term><term>Liposomes</term></keywords><keywords scheme="MESH" type="chemical" qualifier="ultrastructure" xml:lang="en"><term>Liposomes</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Nanoparticles</term></keywords><keywords scheme="MESH" qualifier="ultrastructure" xml:lang="en"><term>Nanoparticles</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Calorimetry, Differential Scanning</term><term>Chromatography, Gas</term><term>Elastic Modulus</term><term>Electrophoresis</term><term>Hydrophobic and Hydrophilic Interactions</term><term>Membrane Fluidity</term><term>Particle Size</term><term>Phase Transition</term><term>Rheology</term><term>Salmon</term><term>Solubility</term><term>Temperature</term><term>Viscosity</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In this work, we studied the effect of nanoliposome composition based on phospholipids of docosahexaenoic acid (PL-DHA), salmon and soya lecithin, on physico-chemical characterization of vector. Cinnamic acid was encapsulated as a hydrophobic molecule in nanoliposomes made of three different lipid sources. The aim was to evaluate the influence of membrane lipid structure and composition on entrapment efficiency and membrane permeability of cinnamic acid. These properties are important for active molecule delivery. In addition, size, electrophoretic mobility, phase transition temperature, elasticity and membrane fluidity were measured before and after encapsulation. The results showed a correlation between the size of the nanoliposome and the entrapment. The entrapment efficiency of cinnamic acid was found to be the highest in liposomes prepared from salmon lecithin. The nanoliposomes composed of salmon lecithin presented higher capabilities as a carrier for cinnamic acid encapsulation. These vesicles also showed a high stability which in turn increases the membrane rigidity of nanoliposome as evaluated by their elastic properties, membrane fluidity and phase transition temperature.</div></front></TEI><affiliations><list><country><li>France</li><li>Italie</li><li>États-Unis</li></country><region><li>Alsace-Champagne-Ardenne-Lorraine</li><li>Californie</li><li>Lorraine</li></region><settlement><li>Vandoeuvre-Lès-Nancy</li></settlement><orgName><li>Université de Lorraine</li></orgName></list><tree><country name="France"><region name="Alsace-Champagne-Ardenne-Lorraine"><name sortKey="Bouarab, Lynda" sort="Bouarab, Lynda" uniqKey="Bouarab L" first="Lynda" last="Bouarab">Lynda Bouarab</name></region><name sortKey="Arab Tehrany, Elmira" sort="Arab Tehrany, Elmira" uniqKey="Arab Tehrany E" first="Elmira" last="Arab-Tehrany">Elmira Arab-Tehrany</name><name sortKey="Hasan, Mahmoud" sort="Hasan, Mahmoud" uniqKey="Hasan M" first="Mahmoud" last="Hasan">Mahmoud Hasan</name><name sortKey="Linder, Michel" sort="Linder, Michel" uniqKey="Linder M" first="Michel" last="Linder">Michel Linder</name><name sortKey="Maherani, Behnoush" sort="Maherani, Behnoush" uniqKey="Maherani B" first="Behnoush" last="Maherani">Behnoush Maherani</name></country><country name="États-Unis"><region name="Californie"><name sortKey="Kheirolomoom, Azadeh" sort="Kheirolomoom, Azadeh" uniqKey="Kheirolomoom A" first="Azadeh" last="Kheirolomoom">Azadeh Kheirolomoom</name></region></country><country name="Italie"><noRegion><name sortKey="Aliakbarian, Bahar" sort="Aliakbarian, Bahar" uniqKey="Aliakbarian B" first="Bahar" last="Aliakbarian">Bahar Aliakbarian</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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